Article

Antibodies against the capsid induced after intracranial AAV administration limits second administration in a dose dependent manner

2024-09-19

Abstract excerpt

Recombinant adeno-associated virus (rAAV) is a widely used viral vector for gene therapy. However, a limitation of AAV-mediated gene therapy is that patients are typically dosed only once. In this study, we investigated the possiblility to deliver multiple rounds of AAV through intracerebral injections in the mouse brain. We discovered a dose-dependent modulation of the second round AAV infection by the first roun...

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Identifiers and source

Literature Corpus work: c3d897d3-2690-5740-a791-2466322e2995
DOI: 10.1101/2024.09.15.612566

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