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Article

Targeted immunosuppression enhances repeated gene delivery

2022-03-01

Abstract excerpt

<title>Abstract</title> <p>Adeno-associated virus (AAV) vector-based gene therapies can be applied to a wide range of diseases. AAV expression can last for months to years, but vector re-administration may be necessary to achieve life-long treatment. Unfortunately, immune system response against these vectors is potentiated after the first administration, which prevents the clinical use of repeated administration...

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Literature Corpus work
29de6297-1afd-5c13-ba7e-123b94bba3be
DOI
10.21203/rs.3.rs-1382849/v1
Open publication

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Targeted immunosuppression enhances repeated gene deliveryDOI 10.21203/rs.3.rs-1382849/v1
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