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Article

Adeno-Associated Virus Serotype 9 Transduction in the Central Nervous System of Nonhuman Primates

27 Dec 2011

Abstract excerpt

Widespread distribution of gene products at clinically relevant levels throughout the CNS has been challenging. Adeno-associated virus type 9 (AAV9) vector has been reported as a good candidate for intravascular gene delivery, but low levels of preexisting antibody titers against AAV in the blood abrogate cellular transduction within the CNS. In the present study we compared the effectiveness of vascular delivery...

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Identifiers

PMID: 22201473
DOI: 10.1089/hum.2011.200

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