Article
Cross-talk between aging and cancer: the epigenetic language.
Annals of the New York Academy of Sciences - 1 Apr 2007
Fraga Mario F, Agrelo Ruben, Esteller Manel
Abstract excerpt
The risk of having cancer increases with age probably because progenitor cells from mature organisms accumulate enough molecular lesions to evade the homeostatic control of their tissular contexts. Molecular lesions can be genetic (mutations, deletions, or translocations) and/or epigenetic. Epigenetic signaling, including DNA methylation and histone modification, is essential for normal development and becomes...
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