Article

Hepatitis B virus resistance to tenofovir: fact or fiction? A systematic literature review and structural analysis of drug resistance mechanisms

2020-06-29

Abstract excerpt

<h4>Background: </h4> Tenofovir (TFV) is a widely used treatment for chronic hepatitis B virus (HBV) infection. There is a high genetic barrier to the selection of TFV resistance-associated mutations (RAMs), but the distribution and clinical significance of TFV RAMs are not well understood. We here present assimilated evidence for putative TFV RAMs with the aims of cataloguing and characterising mutations that hav...

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Literature Corpus work: c3721d3b-e265-563c-9a00-f0c8ce99b3fa
DOI: 10.12688/wellcomeopenres.15992.1

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