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The NKCC1 inhibitor bumetanide has no discernible effect on plasma cell survival, persistence or antibody secretion

2026-05-26

Abstract excerpt

Long-lived plasma cells (LLPC) sustain humoral immunity but also contribute to the persistence of pathogenic autoantibodies in autoimmune diseases. New therapies targeting LLPC are therefore desirable. Recent studies have shown increased expression of Slc12a2 , encoding the Na + -K + -Cl − cotransporter (NKCC1), in LLPC. This study investigated whether NKCC1 activity was required for plasma cell survival, pers...

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Literature Corpus work
c31c49f8-c6fa-5a98-a39d-83532749f0fc
DOI
10.64898/2026.05.22.727109
Open publication

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