Article

Distinct mitochondrial DNA single-nucleotide variant signatures in TOP3A-deficient cardiomyocytes

2026-08-22

Abstract excerpt

The human heart has a continuous and exceptionally high demand for energy, which is met primarily through mitochondrial oxidative phosphorylation. This dependence places the maintenance and integrity of mitochondrial DNA (mtDNA) for proper mitochondrial function at the center of cardiac health, as mtDNA instability has been shown to cause mitochondrial dysfunction, which can ultimately impair cardiac function lead...

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Literature Corpus work: c2ff3f3d-4119-5449-8ecb-6459d12a41b5
DOI: 10.64898/2026.08.18.745450

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