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Top-down Proteomics of Myosin Light Chain Isoforms Define Chamber-Specific Expression in the Human Heart

2023-01-27

Abstract excerpt

Myosin functions as the “molecular motor” of the sarcomere and generates the contractile force necessary for cardiac muscle contraction. Myosin light chains 1 and 2 (MLC-1 and -2) play important functional roles in regulating the structure of the hexameric myosin molecule. Each of these light chains has an ‘atrial’ and ‘ventricular’ isoform, so called because they are believed to exhibit chamber-restricted express...

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Literature Corpus work
c2f28449-c499-5c3c-b271-6a2c63aff2ee
DOI
10.1101/2023.01.26.525767
Open publication

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Top-down Proteomics of Myosin Light Chain Isoforms Define Chamber-Specific Expression in the Human HeartDOI 10.1101/2023.01.26.525767
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