Article

Expression of a RAS degrader via synthetic nanocarrier-mediated mRNA delivery reduces pancreatic tumors

2024-06-14

Abstract excerpt

<h4>ABSTRACT</h4> Therapeutic gene expression can address many of the challenges associated with the controlled delivery of intracellularly active biologics, such as enzymes that degrade RAS for treatment of RAS-driven cancers. Here, we demonstrate that an optimized synthetic nonviral gene delivery platform composed of poly(ethylene glycol)- b -poly(propylene sulfide) (PEG-PPS) can block copolymers conjugated to...

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Literature Corpus work: c2beb174-4034-579c-9d30-efacccfea16b
DOI: 10.1101/2024.06.11.598439

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