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Personalized medicine in pancreatic cancer: Harnessing the potential of mRNA vaccines

17 Feb 2025

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal cancer with a five-year survival rate of just 7%. Its late diagnosis and limited treatment options contribute to poor outcomes. Immunotherapy has had little success due to PDAC's dense and immunosuppressive tumor environment. Emerging mRNA vaccines, such as autogene cevumeran (BNT122), show promise in enhancing treatment. Preliminary trials have reported...

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PMID: 40074443
DOI: 10.1016/j.jgeb.2025.100469

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