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Article

Using Extracellular miRNA Signatures to Identify Patients with LRRK2-Related Parkinson's Disease.

Journal of Parkinson's disease - 1 Jan 2024

Braunger Luca Jannik, Knab Felix, Gasser Thomas

Abstract excerpt

Background: Mutations in the Leucine Rich Repeat Kinase 2 gene are highly relevant in both sporadic and familial cases of Parkinson's disease. Specific therapies are entering clinical trials but patient stratification remains challenging. Dysregulated microRNA expression levels have been proposed as biomarker candidates in sporadic Parkinson's disease. Objective: In this proof-of concept study we evaluate the...

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Identifiers

PMID: 38848197
DOI: 10.3233/JPD-230408
PMCID: PMC11307038

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