Article

A Prospective Pharmacogenetic Phase 3 Clinical Trial of Low-Dose Ondansetron (A 5-HT3 Antagonist) to Treat Heavy and Very Heavy Drinkers With Alcohol Use Disorder

2022-10-18

Abstract excerpt

This 6-month, double-blind, randomized, Phase-3 clinical trial of individuals with Alcohol Use Disorder (AUD) assessed the efficacy of ondansetron 0.33 mg/twice daily (AD04) vs placebo at reducing the Percentage of Heavy Drinking Days (PHDD) among a genetic subgroup with variations at the serotonin transporter and 5-HT3A/5-HT-3B receptors who consumed <10 Standard Drinks/Drinking Day (DDD) (heavy drinkers) or ≥10...

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Literature Corpus work: c2a06b5d-9600-5e9a-b6aa-b8df2a3a6a2b
DOI: 10.21203/rs.3.rs-2156237/v1

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