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Article

Ondansetron reduces naturalistic drinking in nontreatment-seeking alcohol-dependent individuals with the LL 5'-HTTLPR genotype: a laboratory study.

Alcoholism, clinical and experimental research - 1 Jun 2014

Kenna George A, Zywiak William H, Swift Robert M, McGeary John E, Clifford James S, Shoaff Jessica R, Vuittonet Cynthia, Fricchione Samuel, Brickley Michael, Beaucage Kayla, Haass-Koffler Carolina L, Leggio Lorenzo

Abstract excerpt

BACKGROUND: One hypothesis suggests that the differential response to ondansetron- and serotonin-specific re-uptake inhibitors (SSRIs) may be due to a functional polymorphism of the 5'-HTTLPR promoter region in SLC6A4, the gene that codes for the serotonin transporter (5-HTT). The LL 5'-HTTLPR ge...

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Identifiers

PMID: 24773166
DOI: 10.1111/acer.12410
PMCID: PMC4047179

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24773166-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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