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Article

Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking.

The American journal of psychiatry - 1 Mar 2011

Johnson Bankole A, Ait-Daoud Nassima, Seneviratne Chamindi, Roache John D, Javors Martin A, Wang Xin-Qun, Liu Lei, Penberthy J Kim, DiClemente Carlo C, Li Ming D

Abstract excerpt

OBJECTIVE: Severe drinking can cause serious morbidity and death. Because the serotonin transporter (5-HTT) is an important regulator of neuronal 5-HT function, allelic differences at that gene may modulate the severity of alcohol consumption and predict therapeutic response to the 5-HT(3) receptor antagonist, ondansetron. METHOD: The authors randomized 283 alcoholics by genotype in the 5'-regulatory region of...

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Source

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Identifiers

PMID: 21247998
DOI: 10.1176/appi.ajp.2010.10050755
PMCID: PMC3063997

Genes

HTT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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