Article

Metformin may improve the outcome of patients with breast cancer and type 2 diabetes mellitus through the effect of tumor immune microenvironment.

2023-08-23

Abstract excerpt

<title>Abstract</title> <p>The antidiabetic drug metformin has antitumor effects. We examined the outcome of 177 patients with type 2 diabetes mellitus who received surgery for breast cancer. Among them, 49 patients were treated with metformin. In those patients, recurrence in distant organs was less frequent and postoperative disease-free survival tended to be better than in those without metformin intake. In pa...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2944b97-aaf6-5dc8-bd59-bd1d6fcf83a8
DOI: 10.21203/rs.3.rs-3271592/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metformin may improve the outcome of patients with breast cancer and type 2 diabetes mellitus through the effect of tumor immune microenvironment.DOI 10.21203/rs.3.rs-3271592/v1Read

Metformin May Block the Way Breast Cancer Metastasis: A Meta-analysis and Mechanism ReviewSemantic proximity Read

COX-2 Expression Correlation with Tumor-Associated Macrophages Infiltration and Prognosis in Gastric CancerSemantic proximity Read

Anti-tumor activity of metformin: from metabolic and epigenetic perspectivesSemantic proximity Read

Metformin for the treatment of breast cancer: a scoping review of randomized clinical trialsSemantic proximity Read

Hydroxypropyl-β-cyclodextrin inhibits the development of triple negative breast cancer by enhancing antitumor immunitySemantic proximity Read

Effects of Metformin on Transcriptomic and Metabolomic Profiles in Breast Cancer Survivors Enrolled in the Randomized Placebo-Controlled MetBreCS TrialSemantic proximity Read

Inhibition of STAT3 by 2-Methoxyestradiol suppresses M2 polarization and protumoral functions of macrophages in breast cancerSemantic proximity Read

Metformin: an old drug with potential therapeutic function in antitumorSemantic proximity Read

Tumor-associated macrophages of the M1/M2 phenotype are involved in the regulation of malignant biological behavior of breast cancer cells through the EMT pathway.Semantic proximity Read

Metformin effects on malignant cells and healthy PBMC; the influence of metformin on the phenotype of breast cancer cells.Semantic proximity Read

Insulin: The Hidden Link Between Type 2 Diabetes and Cancer Metastasis – Driving metastatic potential of SKOV3 cancer cells via Epithelial-Mesenchymal Transition mechanismSemantic proximity Read

Peptide-guided resiquimod-loaded lignin nanoparticles convert tumor-associated macrophages from M2 to M1 phenotype for enhanced chemotherapy.Semantic proximity Read