Article
Metformin effects on malignant cells and healthy PBMC; the influence of metformin on the phenotype of breast cancer cells.
Pathology oncology research : POR - 1 Jul 2015
Damjanović Ana, Matić Ivana Z, Ðorđić Marija, Ðurović Marina Nikolić, Nikolić Srđan, Roki Ksenija, Milovanović Zorka, Antić-Stanković Jelena, Džodić Radan, Damjanović Svetozar, Kanjer Ksenija, Abu Rabi Zaki, Juranić Zorica
Abstract excerpt
The aim of research was to determine the effects of maximally therapeutically achievable concentrations of metformin on malignant cells and healthy peripheral blood mononuclear cells (PBMC). Eight patients with T2D or hyperglycemia and nine healthy volunteers were included in the study. For determination of the influence of metformin on the phenotype of breast carcinoma, 1,410 patients with surgically removed...
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