Article
A systematic genetic analysis in <i>Neisseria meningitidis</i> defines the Pil proteins required for assembly, functionality, stabilization and export of type IV pili
10 Aug 2006
Abstract excerpt
Although type IV pili (Tfp) are among the commonest virulence factors in bacteria, their biogenesis by complex machineries of 12-15 proteins, and thereby their function remains poorly understood. Interestingly, some of these proteins were reported to merely antagonize the retraction of the fibres powered by PilT, because piliation could be restored in their absence by a mutation in the pilT gene. The recent...
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