Article

Soluble amyloid-beta buffering by plaques in Alzheimer disease dementia versus high-pathology controls

2017-11-29

Abstract excerpt

An unanswered question regarding Alzheimer disease dementia (ADD) is whether amyloid-beta (Aβ) plaques sequester toxic soluble Aβ species early in the pathological progression. We previously reported that the concentration of soluble Aβ aggregates from patients with mild dementia was higher than soluble Aβ aggregates from patients with modest Aβ plaque burden but no dementia. The ratio of soluble Aβ aggregate conc...

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Literature Corpus work: c24d86f6-6ebe-5d2f-8f93-6fc99eb1c458
DOI: 10.1101/227009

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