Article
Quantification of Alzheimer pathology in ageing and dementia: age-related accumulation of amyloid-beta(42) peptide in vascular dementia.
Neuropathology and applied neurobiology - 1 Apr 2006
Lewis H, Beher D, Cookson N, Oakley A, Piggott M, Morris C M, Jaros E, Perry R, Ince P, Kenny R A, Ballard C G, Shearman M S, Kalaria R N
Abstract excerpt
Clinicopathological observations suggest there is considerable overlap between vascular dementia (VaD) and Alzheimer's disease (AD). We used immunochemical methods to compare quantities of amyloid-beta (Abeta) peptides in post mortem brain samples from VaD, AD subjects and nondemented ageing controls. Total Abeta peptides extracted from temporal and frontal cortices were quantified using a previously...
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