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α-1,3-Glucan-Driven Remodeling of the Conidial Cell Wall in an <i>Aspergillus fumigatus</i> Vaccine Strain Alters Innate Immune Recognition

2026-01-02

Abstract excerpt

<h4>ABSTRACT</h4> Aspergillus fumigatus is a major cause of invasive aspergillosis in immunocompromised patients, where current antifungal therapies are limited by toxicity, drug resistance, and lack of durable protection, and no vaccines are available. A mutant lacking the sterylglucosidase-encoding gene ( sglA ) has emerged as a candidate that induces protective immune responses, but the structural basis for t...

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Literature Corpus work
c231bdab-30b8-53fc-83bd-9a71039cc7e0
DOI
10.64898/2025.12.31.697239
Open publication

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α-1,3-Glucan-Driven Remodeling of the Conidial Cell Wall in an <i>Aspergillus fumigatus</i> Vaccine Strain Alters Innate Immune RecognitionDOI 10.64898/2025.12.31.697239
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