Article

Efficacy of vafidemstat in experimental autoimmune encephalomyelitis highlights the KDM1A/RCOR1/HDAC epigenetic axis in multiple sclerosis

2021-02-02

Abstract excerpt

<title>Abstract</title> <p><bold>Background </bold>Vafidemstat (ORY-2001) is a clinical stage inhibitor of the Lysine Specific Demethylase KDM1A in development for treatment of neurodegenerative and psychiatric diseases. KDM1A demethylates H3K4me1/2 and together with the histone deacetylases HDAC1/2, it forms part of co-repressor complexes recruited by zinc finger factors to control transcription. The exact role...

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Literature Corpus work: 2cd3125c-7009-51ac-9cd1-0f2df96a15ab
DOI: 10.21203/rs.3.rs-114482/v5

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