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The Impact of Mechanical Circulatory Support Devices on White Blood Cell Phenotype and Function.

Cardiovascular engineering and technology - 1 Aug 2025

Li Zhuo, Wei Zhenling, Su Wangwang, Cheng Longhui, Zhang Liudi

Abstract excerpt

BACKGROUND: Mechanical circulatory support devices (MCSDs) have gradually become an effective treatment of end-stage heart failure (HF). However, the introduction of foreign surfaces and non-physiological shear stress (NPSS) can cause severe damage to various blood cells, leading to impaired function of immune system and increased risk of complications such as inflammation and thrombosis. The effect of mechanical...

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PMID: 40251454
DOI: 10.1007/s13239-025-00784-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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