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Targeted repression of DNA topoisomerase I by CRISPRi reveals a critical function for it in the <i>Chlamydia trachomatis</i> developmental cycle

2023-03-14

Abstract excerpt

Chlamydia trachomatis is an obligate intracellular bacterium that is responsible for the most prevalent bacterial sexually transmitted infections. Changes in DNA topology in this pathogen have been linked to its pathogenicity-associated developmental cycle. Here, evidence is provided that the balanced activity of DNA topoisomerases (Topos) contributes to Chlamydia developmental processes. Utilizing catalytically...

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Identifiers and source

Literature Corpus work
c208627c-ac31-5f22-b051-3b1948cd5e2b
DOI
10.1101/2023.03.14.532001
Open publication

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Targeted repression of DNA topoisomerase I by CRISPRi reveals a critical function for it in the <i>Chlamydia trachomatis</i> developmental cycleDOI 10.1101/2023.03.14.532001
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