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Identification of the alternative sigma factor regulons of Chlamydia trachomatis using multiplexed CRISPR interference

25 Sept 2023

Abstract excerpt

ABSTRACT Chlamydia trachomatis is a developmentally regulated, obligate intracellular bacterium that encodes three sigma factors: σ66, σ54, and σ28. σ66 is the major sigma factor controlling most transcription initiation during early- and mid-cycle development as the infectious elementary body (EB) transitions to the non-infectious reticulate body (RB) that replicates within an inclusion inside the cell. The...

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PMID: 37747235
DOI: 10.1128/msphere.00391-23

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