Article
An impedance-based approach using human iPSC-derived cardiomyocytes significantly improves in vitro prediction of in vivo cardiotox liabilities.
Toxicology and applied pharmacology - 15 Aug 2017
Koci Bryan, Luerman Gregory, Duenbostell Anika, Kettenhofen Ralf, Bohlen Heribert, Coyle Luke, Knight Brian, Ku Warren, Volberg Walter, Woska Joseph R, Brown Martha P
Abstract excerpt
Current in vitro approaches to cardiac safety testing typically focus on mechanistic ion channel testing to predict in vivo proarrhythmic potential. Outside of the Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative, structural and functional cardiotoxicity related to chronic dosing effects are of great concern as these effects can impact compound attrition. Development and implementation of an in vitro...
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