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Article

Pathogenesis of NUT Midline Carcinoma

2 Mar 2011

Abstract excerpt

NUT midline carcinoma (NMC), an aggressive form of squamous cell carcinoma, is defined by the presence of acquired chromosomal rearrangements involving NUT, usually BRD4-NUT fusion genes and, less commonly, NUT-variant fusion genes involving BRD3 or still-uncharacterized genes. Improved diagnostic tests reveal that although rare, NMCs occur in people of any age and may be indistinguishable from more common...

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PMID: 22017582
DOI: 10.1146/annurev-pathol-011811-132438

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