Article

SOX2 is a dispensable modulator of NUT carcinoma oncogenesis in mouse

2025-07-14

Abstract excerpt

NUT carcinoma (NC) is a highly aggressive malignancy driven by BRD4::NUTM1 and other NUTM1 fusion oncogenes. BRD4::NUTM1 aberrantly activates transcription factors (TFs) linked to basal progenitor identity, producing poorly differentiated squamous phenotypes. Among these TFs, SOX2 has been proposed as a critical oncogenic driver, but its functional requirement in NC has not been tested in vivo. Using a genetically...

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Identifiers and source

Literature Corpus work: 935b005d-2cbc-5414-b5ad-363846193ecb
DOI: 10.1101/2025.07.09.664010

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