Article
Mitochondrial DNA rearrangements, including partial duplications, occur in young and old rat tissues.
Mutation research - 3 Nov 1998
Moore C A, Gudikote J, Van Tuyle G C
Abstract excerpt
Using polymerase chain reaction (PCR) with back-to-back primers, 85 different mitochondrial DNA (mtDNA) rearrangements, consisting of partial duplications or mini-circles, were detected in brain, liver, and heart tissue from Fischer 344 rats. The regions around the mitochondrial tRNALeu(UUR) gene...
Topics
- Aging
- Animals
- Base Sequence
- DNA Mutational Analysis
- DNA Primers
- DNA, Mitochondrial
- Gene Duplication
- Gene Rearrangement
- Molecular Sequence Data
- Mutation
- Nucleic Acid Conformation
- Polymerase Chain Reaction
- RNA, Ribosomal, 16S
- RNA, Transfer, Leu
- Rats
- Rats, Inbred F344