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Voltage-Dependent Ca <sup>2+</sup> Release Is Impaired in Hypokalemic Periodic Paralysis Caused by Ca <sub>V</sub> 1.1-R528H but not by Na <sub>V</sub> 1.4-R669H

2022-05-19

Abstract excerpt

<h4>ABSTRACT</h4> Hypokalemic periodic paralysis (HypoPP) is a channelopathy of skeletal muscle caused by missense mutations in the voltage sensor domains (usually at an arginine of the S4 segment) of the Ca V 1.1 calcium channel or of the Na V 1.4 sodium channel. The primary clinical manifestation is recurrent attacks of weakness, resulting from impaired excitability of anomalously depolarized fibers containin...

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Literature Corpus work
c15b53af-77b7-5dca-b1b8-118d3d882be9
DOI
10.1101/2022.05.17.492380
Open publication

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Voltage-Dependent Ca <sup>2+</sup> Release Is Impaired in Hypokalemic Periodic Paralysis Caused by Ca <sub>V</sub> 1.1-R528H but not by Na <sub>V</sub> 1.4-R669HDOI 10.1101/2022.05.17.492380
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