Channelopathies of skeletal muscle excitability.

doi:10.1002/cphy.c140062

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Article

Channelopathies of skeletal muscle excitability.

Comprehensive Physiology - 1 Apr 2015

Cannon Stephen C

Abstract excerpt

Familial disorders of skeletal muscle excitability were initially described early in the last century and are now known to be caused by mutations of voltage-gated ion channels. The clinical manifestations are often striking, with an inability to relax after voluntary contraction (myotonia) or transient attacks of severe weakness (periodic paralysis). An essential feature of these disorders is fluctuation of...

Topics

Channelopathies
Humans
Ion Channel Gating
Ion Channels
Models, Biological
Muscle Contraction
Muscle, Skeletal
Muscular Diseases
Mutation

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Identifiers

PMID: 25880512
DOI: 10.1002/cphy.c140062
PMCID: PMC4754081

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