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Article

A calcium channel mutant mouse model of hypokalemic periodic paralysis.

The Journal of clinical investigation - 1 Dec 2012

Wu Fenfen, Mi Wentao, Hernández-Ochoa Erick O, Burns Dennis K, Fu Yu, Gray Hillery F, Struyk Arie F, Schneider Martin F, Cannon Stephen C

Abstract excerpt

Hypokalemic periodic paralysis (HypoPP) is a familial skeletal muscle disorder that presents with recurrent episodes of severe weakness lasting hours to days associated with reduced serum potassium (K+). HypoPP is genetically heterogeneous, with missense mutations of a calcium channel (Ca(V)1.1) or a sodium channel (Na(V)1.4) accounting for 60% and 20% of cases, respectively. The mechanistic link between Ca(V)1.1...

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Source

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Identifiers

PMID: 23187123
DOI: 10.1172/JCI66091
PMCID: PMC3533564

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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