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Article

Hypokalemic periodic paralysis: novel perspectives from genetic mutations to clinical management.

Gene - 15 Jul 2026

Gao Zhe, Xing Hanying, Zhang Juan, Chen Shuting, Gao Zhe

Abstract excerpt

Hypokalemic periodic paralysis (HypoPP) is an autosomal dominant neuromuscular disorder characterized by episodic flaccid weakness with hypokalemia. It is primarily caused by mutations in the CACNA1S gene, encoding the voltage-gated calcium channel Cav1.1, and the SCN4A gene, encoding the voltage-gated sodium channel Nav1.4. A unified pathophysiological mechanism proposes that these mutations neutralize...

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Source

Identifiers

PMID: 42013926
DOI: 10.1016/j.gene.2026.150172

Genes

CACNA1S
SCN4A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 15 Oct 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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