Article

Targeting G protein-coupled receptor-17 (GPR17) upregulation in paediatric diffuse midbrain gliomas leads to altered phenotype and susceptibility to therapies

2020-11-17

Abstract excerpt

Paediatric diffuse midline glioma (pDMG) also known as Diffuse intrinsic pontine gliomas (DIPG) is an incurable, aggressive childhood brain malignancy, that arises in a region- and age-specific nature. The underlying pathophysiology suggests dysregulation of postnatal neurodevelopmental processes causing aborted cell differentiation. The cell of origin is unclear, but data suggests an oligodendrocytic lineage (OPC...

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Literature Corpus work: c12fe2af-d279-52fd-8796-af0bc558a9df
DOI: 10.1101/2020.11.17.386706

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