Article

Why Clinical Trials Stop: The Role of Genetics

2023-02-08

Abstract excerpt

Many drug discovery projects are started, but few progress fully through clinical trials to approval. Previous work has shown that human genetics support for the therapeutic hypothesis increases the chance of trial progression. Here, we applied natural language processing to classify the freetext reasons for 28,842 clinical trials that stopped before their endpoints were met. We then evaluated these classes in the...

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Literature Corpus work: c121bc36-29cd-5b05-b7a2-579a854edc3a
DOI: 10.1101/2023.02.07.23285407

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