Article

Drug approval prediction based on the discrepancy between gene perturbation effects in cells and humans

2022-08-11

Abstract excerpt

<title>Abstract</title> <p>Safety failures in clinical trials increase the cost of drug development. Appropriate drug target selection with minimal toxicity is critical for successful drug development. However, the discrepancy in drug target perturbation effects between cells and humans results in safety failures of drugs with poor translatability between preclinical and clinical research. To address this issue,...

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Literature Corpus work: 731a0313-7e3d-5fcf-b2fb-e447933c650d
DOI: 10.21203/rs.3.rs-1932224/v1

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