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Article

Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130.

Gastroenterology - 1 Jan 2004

Judd Louise M, Alderman Barbara M, Howlett Meegan, Shulkes Arthur, Dow Chris, Moverley Jill, Grail Diane, Jenkins Brendan J, Ernst Matthias, Giraud Andrew S

Abstract excerpt

BACKGROUND AND AIMS: We have developed a mouse model of gastric cancer that resembles human intestinal-type adenocarcinoma. The aim of this study was to determine the identity and temporal changes in mediators of IL-6 signaling regulating tumor development. METHODS: gp130(757F/F) Mice that lack the SHP2-binding site on the IL-6 family receptor gp130 and have increased STAT 3 activity and wild-type littermates...

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Source

Identifiers

PMID: 14699500
DOI: 10.1053/j.gastro.2003.10.066

Genes

TFF1
EGF
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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