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Subversion of Host Innate Immunity by Human Papillomavirus Oncoproteins

17 Apr 2020

Abstract excerpt

The growth of human papillomavirus (HPV)-transformed cells depends on the ability of the viral oncoproteins E6 and E7, especially those from high-risk HPV16/18, to manipulate the signaling pathways involved in cell proliferation, cell death, and innate immunity. Emerging evidence indicates that E6/E7 inhibition reactivates the host innate immune response, reversing what until then was an unresponsive cellular...

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PMID: 32316236
DOI: 10.3390/pathogens9040292

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