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Article

Validation of a Clinical and Polygenic Risk Prediction Model for Ovarian Cancer in the Nurses' Health Study.

Cancer prevention research (Philadelphia, Pa.) - 6 Feb 2026

Patel Krishna, Dite Gillian S, Spaeth Erika L, Rosner Bernard A

Abstract excerpt

Ovarian cancer is the leading cause of death among gynecologic cancers because of its late diagnosis, but risk stratification for targeted prevention can improve outcomes. To identify women at risk of ovarian cancer, pathogenic variant testing is used, especially for those with a family history of the disease. However, high-risk genetic variants are rare, accounting for <20% of ovarian cancer cases overall. More...

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Identifiers

PMID: 41215703
DOI: 10.1158/1940-6207.CAPR-24-0528
PMCID: PMC12877746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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