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Convergent utilization of APN receptor by hedgehog merbecoviruses

2026-02-18

Abstract excerpt

<title>Abstract</title> <p>Dipeptidyl peptidase-4 (DPP4) and angiotensin-converting enzyme 2 (ACE2) are well-established receptors for merbecoviruses, yet the receptor usage of merbecoviruses of European and Asian hedgehogs (EriCoVs) remains unknown. Here, by testing hedgehog orthologs of known coronavirus receptors, we identify hedgehog aminopeptidase N (APN) as a functional receptor for various EriCoVs. Analysi...

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Identifiers and source

Literature Corpus work
c08d39e1-74bb-5992-973b-c810f48b8252
DOI
10.21203/rs.3.rs-8368823/v1
Open publication

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Convergent utilization of APN receptor by hedgehog merbecovirusesDOI 10.21203/rs.3.rs-8368823/v1
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