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Close relatives of MERS-CoV in bats use ACE2 as their functional receptors

7 Dec 2022

Abstract excerpt

Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) and several bat coronaviruses use dipeptidyl peptidase-4 (DPP4) as an entry receptor 1–4 . However, the receptor for NeoCoV—the closest known MERS-CoV relative found in bats—remains unclear 5 . Here, using a pseudotype virus entry assay, we found that NeoCoV and its close relative, PDF-2180, can efficiently bind to and use specific bat...

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PMID: 36477529
DOI: 10.1038/s41586-022-05513-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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