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Article

Single-cell ATAC sequencing identifies sleepy macrophages during reciprocity of cytokines in L. major infection

1 Feb 2024

Abstract excerpt

ABSTRACT The hallmark characteristic of macrophages lies in their inherent plasticity, allowing them to adapt to dynamic microenvironments. Leishmania strategically modulates the phenotypic plasticity of macrophages, creating a favorable environment for intracellular survival and persistent infection through regulatory cytokine such as interleukin (IL)-10. Nevertheless, these effector cells can counteract...

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PMID: 38299832
DOI: 10.1128/spectrum.03478-23

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