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Article

Age is an important independent modifier of SCA3 phenotype severity.

Neuroscience letters - 10 Jan 2021

Jiao Shujun, Wang Puzhi, Chen Zhao, Wang Chunrong, Shi Yuting, Qiu Rong, Tang Beisha, Jiang Hong

Abstract excerpt

OBJECTIVE: This study aimed to investigate factors modulating spinocerebellar ataxia type 3 (SCA3) phenotype severity besides the expanded CAG repeats (ExpCAG) of ATXN3. METHODS: Data regarding CAG trinucleotide repeats, age at onset (AO), duration, age, sex, transmitting parent, and scale scores of SCA3 patients were collected. Multiple linear regression analysis was performed to identify influential independent...

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Source

Identifiers

PMID: 33221475
DOI: 10.1016/j.neulet.2020.135510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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