Article

Tlr4 and Nlrp3 Inflammasome Signaling Drive a Delayed Secondary Wave of Hyperexcitability After TBI in Larval Zebrafish: Implications for Post-Traumatic Epileptogenesis

2026-08-05

Abstract excerpt

Post-traumatic epilepsy (PTE) develops in a substantial subset of traumatic brain injury (TBI) survivors through epileptogenic mechanisms that remain undefined and untreatable. Neuroinflammation is a key co-occurring mechanism long suspected to drive the transition of TBI-induced seizures into PTE, but anti-inflammatory interventions have thus far failed clinically, likely because of mistimed or misdirected therap...

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Literature Corpus work: bf9a8535-a3bf-530f-9fe3-2d294f1609e4
DOI: 10.64898/2026.07.31.742143

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