Article

Seizures are a druggable mechanistic link between TBI and subsequent tauopathy

2020-05-14

Abstract excerpt

<h4>Summary</h4> Traumatic brain injury (TBI) is a prominent risk factor for neurodegenerative diseases and dementias including chronic traumatic encephalopathy (CTE). TBI and CTE, like all tauopathies, are characterized by accumulation of Tau into aggregates that progressively spread to other brain regions in a prion-like manner. The mechanisms that promote spreading and cellular uptake of tau seeds after TBI ar...

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Literature Corpus work: 944fddd1-eea3-5ea4-8875-e2307ea59c82
DOI: 10.1101/2020.05.12.091819

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