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Host and parasite responses in human diffuse cutaneous leishmaniasis caused by L. amazonensis

7 Mar 2019

Abstract excerpt

Diffuse cutaneous leishmaniasis (DCL) is a rare form of leishmaniasis where parasites grow uncontrolled in diffuse lesions across the skin. Meta-transcriptomic analysis of biopsies from DCL patients infected with Leishmania amazonensis demonstrated an infiltration of atypical B cells producing a surprising preponderance of the IgG4 isotype. DCL lesions contained minimal CD8+ T cell transcripts and no evidence of...

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PMID: 30845223
DOI: 10.1371/journal.pntd.0007152

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