Article

Generation of a bovine cell line for gene engineering using an HIV-1-based lentiviral vector

2022-08-12

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1)-based lentiviral vectors are indispensable tools for gene engineering in mammalian cells. Conversely, lentiviral vector transduction is severely inhibited in bovine cells. Previous studies demonstrated that this inhibition is caused by the anti-lentiviral host factor tripartite motif containing 5 (TRIM5), which targets incoming HIV-1 virions by interacting with the viral...

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Literature Corpus work: bf74b4db-f2ac-5da1-a82b-94c89fd2f812
DOI: 10.21203/rs.3.rs-1913714/v1

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