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Construction of recombinant fluorescent LSDV for high-throughput screening of antiviral drugs

16 Mar 2024

Abstract excerpt

Lumpy skin disease virus (LSDV) infection is a major socio-economic issue that seriously threatens the global cattle-farming industry. Here, a recombinant virus LSDV-ΔTK/EGFP, expressing enhanced green fluorescent protein (EGFP), was constructed with a homologous recombination system and applied to the high-throughput screening of antiviral drugs. LSDV-ΔTK/EGFP replicates in various kidney cell lines, consistent...

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PMID: 38493160
DOI: 10.1186/s13567-024-01281-2

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