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Integrative multi-omics analysis and machine learning refine global histone modification features in prostate cancer

12 Mar 2025

Abstract excerpt

Background: Prostate cancer (PCa) is a major cause of cancer-related mortality in men, characterized by significant heterogeneity in clinical behavior and treatment response. Histone modifications play key roles in tumor progression and treatment resistance, but their regulatory effects in PCa remain poorly understood. Methods: We utilized integrative multi-omics analysis and machine learning to explore histone...

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PMID: 40144021
DOI: 10.3389/fmolb.2025.1557843

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