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Article

Myelin and axon pathology in a long-term study of PMP22-overexpressing mice.

Journal of neuropathology and experimental neurology - 1 May 2011

Verhamme Camiel, King Rosalind H M, ten Asbroek Anneloor L M A, Muddle John R, Nourallah Michelle, Wolterman Ruud, Baas Frank, van Schaik Ivo N

Abstract excerpt

We analyzed clinical and pathological disease in 2 peripheral myelin protein-22 (PMP22) overexpressing mouse models for 1.5 years. C22 mice have 7 and C3-PMP mice have 3 to 4 copies of the human PMP22 gene. C3-PMP mice showed no overt clinical signs at 3 weeks and developed mild neuromuscular impairment; C22 mice showed signs at 3 weeks that progressed to severe impairment. Adult C3-PMP mice had very similar,...

Topics

Action Potentials
Animals
Axons
Demyelinating Diseases
Electrophysiology
Genotype
Mice
Mice, Transgenic
Myelin Proteins
Myelin Sheath
Nerve Fibers, Myelinated

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neuromuscular Diseases

Source

Identifiers

PMID: 21487305
DOI: 10.1097/NEN.0b013e318217eba0

Genes

PMP22

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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