Article
Schwann Cell and the Pathogenesis of Charcot-Marie-Tooth Disease.
Advances in experimental medicine and biology - 1 Jan 2019
Murakami Tatsufumi, Sunada Yoshihide
Abstract excerpt
Charcot-Marie-Tooth (CMT) disease is the most common hereditary neuropathy and genetically heterogeneous. CMT1 and CMTX are autosomal dominant and X-linked demyelinating neuropathies, respectively. CMT1A, CMT1B, and CMTX1 are the common forms of CMT, which are attributed to the genes encoding the myelin or gap junction proteins expressed in the myelinating Schwann cells. CMT4 is a rare autosomal recessive...
Topics
- Axons
- Charcot-Marie-Tooth Disease
- Connexins
- Demyelinating Diseases
- Humans
- Mutation
- Myelin Proteins
- Schwann Cells